Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada

The UWO dataset includes anatomical and fMRI data from 12 monkeys.

Usage Agreement

Creative Commons – Attribution-NonCommercial Share Alike (CC-BY-NC-SA)- Standard INDI data sharing policy. Prohibits use of the data for commercial purposes.

Species

Macaca mulatta

Scanner Specifications

• Siemens Magnetom 7T
• Custom-made 24-channel phased array receive coil with an 8-channel transmit coil.

Gilbert KM, Gati JS, Barker K, Everling S, Menon RS (2016) Optimized parallel transmit and receive radiofrequency coil for ultrahigh-field MRI of monkeys. Neuroimage 125:153-161

Sample Description

• Sample size: 12
• Age distribution: 4-8 years
• Weight distribution: 6.1-11.8 kg
• Sex distribution: All male

Click here for the full sample description (.csv)

Scan Procedures and Parameters

Ethics approval: Experimental procedures on nonhuman primates were in accordance with the Canadian Council of Animal Care policy and a protocol approved by the Animal Use Subcommittee of the University of Western Ontario Council on Animal Care.

Animal care and housing: Pair-housed animals

Any applicable training: none

Scanning preparations

Anesthesia procedures: Animals were first sedated with 0.1-0.2 mg/kg acepromazine, followed by 7.5 mg/kg ketamine hydrochloride by intramuscular injection. Anesthetic induction was accomplished by the administration of 2.5mg/kg propofol via an intravenous catheter in the saphenous vein. Anesthesia was maintained with 1 to 2% isoflurane with oxygen (1.5-2 L/min) through endotracheal intubation and it was reduced to 1% during fMRI acquisition.

Time between anesthesia and scanning: Monkeys were placed in the scanner as soon as isoflurane anesthesia was initiated and stable.

Head fixation: Animal with an implant (see full sample description) were head fixed using a head post.

Position in scanner and procedure used: Sphinx position

Contrast agent: none

During scanning

Physiological monitoring: Heart rate and SpO₂ were monitored throughout via a pulse oximeter and end-tidal CO₂ and respiration rate were monitored via a capnometer.

Additional procedures: Temperature was recorded before and after the scans and was maintained within the normal range using heating discs, covers, and thermal insulation. Animals received subcutaneous fluids (10 ml/kg/hr) before and after the scan.

Scan sequences

• Resting-state:
  • Voxel resolution: 1.0 x 1.0 x 1.0 mm
  • TE: 18ms
  • TR: 1000ms
• Structural:
  • MPRAGE Sequence
  • Voxel resolution: 0.5 x 0.5 x 0.5 mm
  • TE: 3.88ms
  • TR: 65000ms
  • TI: 800ms
  • TI: 2700ms
  • Flip angle: 4°

Click here for scan parameters from the scanner console (pdf).

Publications

• Ghahremani M, Hutchison RM, Menon RS, Everling S (2017) Frontoparietal functional connectivity in the common marmoset. Cerebral Cortex 27 (8): 3890-3905

Personnel

• Stefan Everling¹
• Ravi Menon²

¹Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
²Departments of Medical Biophysics, Medical Imaging, Neuroscience, and Psychiatry, University of Western Ontario, London, Ontario, Canada

Acknowledgements

We would like to thank N. Hague and A. Kirley for expert veterinary care and T. Szekeres and J. Gati for MR expertise.

Funding

• Canadian Institutes of Health Research
• Natural Science and Engineering Research Council
• Brain Canada

Downloads

Click here to download the data. Users will first be prompted to log on to NITRC and will need to register with the 1000 Functional Connectomes Project website on NITRC to gain access to the PRIME-DE datasets.